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Gene | RAD51C |
Variant | D141G |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RAD51C D141G does not lie within any known functional domains of the Rad51c protein (UniProt.org). D141G results in proficient interaction with Rad51b and Xrcc3 and reduced interaction with Rad51d in a yeast assay (PMID: 36099300), but has not been fully biochemically characterized and therefore, its effect on Rad51c protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
RAD51C mutant RAD51C D141G |
Transcript | NM_058216.3 |
gDNA | chr17:g.58696710A>G |
cDNA | c.422A>G |
Protein | p.D141G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_047436505.1 | chr17:g.58696710A>G | c.422A>G | p.D141G | RefSeq | GRCh38/hg38 |
XM_006722001.5 | chr17:g.58696710A>G | c.422A>G | p.D141G | RefSeq | GRCh38/hg38 |
NM_058216.3 | chr17:g.58696710A>G | c.422A>G | p.D141G | RefSeq | GRCh38/hg38 |
XM_006722002.5 | chr17:g.58696710A>G | c.422A>G | p.D141G | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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