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Gene APC
Variant K670*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC K670* results in a premature truncation of the Apc protein at amino acid 670 of 2843 (UniProt.org). K670* has not been characterized, however, due to the effects of other truncation mutations downstream of K670 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC K670*

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Transcript NM_000038.6
gDNA chr5:g.112837602A>T
cDNA c.2008A>T
Protein p.K670*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407450.1 chr5:g.112837602A>T c.2008A>T p.K670* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112837602A>T c.2008A>T p.K670* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112837602A>T c.2008A>T p.K670* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112837602A>T c.2008A>T p.K670* RefSeq GRCh38/hg38
NM_001354906.2 chr5:g.112838451A>T c.2008A>T p.K670* RefSeq GRCh38/hg38
NM_001407470.1 chr5:g.112838451A>T c.2008A>T p.K670* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC K670* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor