APC L1489Yfs*18
Gene Variant Detail

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Gene APC
Variant L1489Yfs*18
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC L1489Yfs*18 indicates a shift in the reading frame starting at amino acid 1489 and terminating 18 residues downstream causing a premature truncation of the 2843 amino acid Apc protein (UniProt.org). L1489Yfs*18 has not been characterized, however, due to the effects of other truncation mutations downstream of L1489 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC L1489fs APC L1489Yfs*18

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Transcript NM_000038.6
gDNA chr5:g.112840060delT
cDNA c.4466delT
Protein p.L1489Yfs*18
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407469.1 chr5:g.112840445_112840446insTACCCCCCCCCCA c.4464_4465insTACCCCCCCCCCA p.L1489Yfs*18 RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112840060delT c.4466delT p.L1489Yfs*18 RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112840060delT c.4466delT p.L1489Yfs*18 RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112840060delT c.4466delT p.L1489Yfs*18 RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112840060delT c.4466delT p.L1489Yfs*18 RefSeq GRCh38/hg38
NM_001407467.1 chr5:g.112840445_112840446insTACCCCCCCCCCA c.4464_4465insTACCCCCCCCCCA p.L1489Yfs*18 RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References