PIK3CA E737Q
Gene Variant Detail

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Gene PIK3CA
Variant E737Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA E737Q lies within the G-loop region of the Pik3ca protein (UniProt.org). E737Q has been identified in sequencing studies (PMID: 37916958, PMID: 37076495), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA E737Q

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Transcript NM_006218.4
gDNA chr3:g.179224102G>C
cDNA c.2209G>C
Protein p.E737Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179224102G>C c.2209G>C p.E737Q RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179224102G>C c.2209G>C p.E737Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References