TP53 Y220H
Gene Variant Detail

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Gene TP53
Variant Y220H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 Y220H lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). Y220H is predicted to result in decreased Tp53 stability and activity based on computer modeling (PMID: 31990523, PMID: 39457600), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 Y220H

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Transcript NM_000546.6
gDNA chr17:g.7674873A>G
cDNA c.658T>C
Protein p.Y220H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407262.1 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674873A>G c.658T>C p.Y220H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References