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Gene TP53
Variant L145P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 L145P lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). L145P has been identified in sequencing studies (PMID: 33933163), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 L145P

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Transcript NM_000546.6
gDNA chr17:g.7675178A>G
cDNA c.434T>C
Protein p.L145P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675178A>G c.434T>C p.L145P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References