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Gene TP53
Variant T150fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 T150fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 150 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). T150fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of T150 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 T150fs

TP53 mutant TP53 inact mut TP53 T150fs

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Transcript NM_000546.6
gDNA chr17:g.(7675164_7675165)
cDNA c.(448_447)
Protein p.T150fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7675164_7675165) c.(448_447) p.T150fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References