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Gene TP53
Variant N235_Y236dup
Impact List duplication
Protein Effect unknown
Gene Variant Descriptions TP53 N235_Y236dup indicates the insertion of two duplicate amino acids, asparagine (N)-235 through tyrosine (Y)-236, in the DNA-binding domain of the Tp53 protein (UniProt.org). N235_Y236dup has been identified in sequencing studies (PMID: 37792634), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 N235_Y236dup

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Transcript NM_000546.6
gDNA chr17:g.7674255_7674260
cDNA c.703_708
Protein p.N235_Y236dup
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674255_7674260 c.703_708 p.N235_Y236dup RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References