TP53 P191del
Gene Variant Detail

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Gene TP53
Variant P191del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 P191del results in the deletion of an amino acid in the DNA-binding domain of the Tp53 protein at amino acid 191 (UniProt.org). P191del has been identified in the scientific literature (PMID: 12010886, PMID: 39649724), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 P191del

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Transcript NM_000546.6
gDNA chr17:g.7674961_7674963delAGG
cDNA c.572_574delCTC
Protein p.P191del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674961_7674963delAGG c.572_574delCTC p.P191del RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References