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Gene | TP53 |
Variant | P191del |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 P191del results in the deletion of an amino acid in the DNA-binding domain of the Tp53 protein at amino acid 191 (UniProt.org). P191del has been identified in the scientific literature (PMID: 12010886, PMID: 39649724), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2025). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon6 TP53 P191del |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674961_7674963delAGG |
cDNA | c.572_574delCTC |
Protein | p.P191del |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |