TP53 V157_I162del
Gene Variant Detail

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Gene TP53
Variant V157_I162del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 V157_I162del results in the deletion of six amino acids in the DNA-binding region of the Tp53 protein from amino acids 157 to 162 (UniProt.org). V157_I162del has been identified in sequencing studies (PMID: 33754015), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 V157_I162del

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Transcript NM_000546.6
gDNA chr17:g.7675127_7675144del18
cDNA c.469_486del18
Protein p.V157_I162del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407270.1 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675127_7675144del18 c.469_486del18 p.V157_I162del RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References