TP53 H193D
Gene Variant Detail

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Gene TP53
Variant H193D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 H193D lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). H193D results in decreased transcriptional activity in patient-derived cells in culture (PMID: 28369373), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 H193D

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Transcript NM_000546.6
gDNA chr17:g.7674954G>C
cDNA c.577C>G
Protein p.H193D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674954G>C c.577C>G p.H193D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
TP53 H193D unknown