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Gene TP53
Variant I255F
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 I255F lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). I255F retains interaction with PPTG1-binding factor in culture (PMID: 25408419) but results in reduced transactivation activity compared to wild-type Tp53 in a reporter assay (PMID: 22710932), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 I255F

TP53 mutant TP53 inact mut TP53 I255F

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Transcript NM_000546.6
gDNA chr17:g.7674200T>A
cDNA c.763A>T
Protein p.I255F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674200T>A c.763A>T p.I255F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References