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Gene | TP53 |
Variant | T253_L257del |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 T253_L257del results in the deletion of five amino acids in the DNA-binding region of the Tp53 protein from amino acids 253 to 257 (UniProt.org). T253_L257del has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon7 TP53 T253_L257del |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674192_7674206del15 |
cDNA | c.757_771del15 |
Protein | p.T253_L257del |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126113.3 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7674192_7674206del15 | c.757_771del15 | p.T253_L257del | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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