TP53 T253_L257del
Gene Variant Detail

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Gene TP53
Variant T253_L257del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 T253_L257del results in the deletion of five amino acids in the DNA-binding region of the Tp53 protein from amino acids 253 to 257 (UniProt.org). T253_L257del has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 T253_L257del

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Transcript NM_000546.6
gDNA chr17:g.7674192_7674206del15
cDNA c.757_771del15
Protein p.T253_L257del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674192_7674206del15 c.757_771del15 p.T253_L257del RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References