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Gene TET2
Variant E1477*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 E1477* results in a premature truncation of the Tet2 protein at amino acid 1477 of 2002 (UniProt.org). E1477* has not been characterized however, due to the effects of other truncation mutations downstream of E1477 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 E1477*

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Transcript NM_001127208.3
gDNA chr4:g.105272810G>T
cDNA c.4429G>T
Protein p.E1477*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024454102.2 chr4:g.105272810G>T c.4429G>T p.E1477* RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105272810G>T c.4429G>T p.E1477* RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105272810G>T c.4429G>T p.E1477* RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105272810G>T c.4429G>T p.E1477* RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TET2 E1477* loss of function - predicted