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Gene TSC2
Variant V225M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TSC2 V225M lies within the TSC1-interacting region of the Tsc2 protein (UniProt.org). V225M has not been characterized in the scientific literature and therefore, its effect on Tsc2 protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

TSC2 mutant TSC2 V225M

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Transcript NM_000548.5
gDNA chr16:g.2056668G>A
cDNA c.673G>A
Protein p.V225M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001363528.2 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
XM_011522636.3 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_001406665.1 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
XM_011522639.3 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_001114382.3 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_000548.5 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_001370405.1 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_001406664.1 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_001077183.3 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
XM_011522637.3 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_001406663.1 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_021055.3 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38
NM_001370404.1 chr16:g.2056668G>A c.673G>A p.V225M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References