ROS1 L2010M
Gene Variant Detail

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Gene ROS1
Variant L2010M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 L2010M lies within the protein kinase domain of the Ros1 protein (UniProt.org). L2010M has been associated with resistance to Ros1 tyrosine kinase inhibitors in the context of a ROS1 fusion in patients (PMID: 38416709), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 L2010M

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Transcript NM_002944.3
gDNA chr6:g.117317250G>T
cDNA c.6028C>A
Protein p.L2010M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536054.3 chr6:g.117318195G>T c.6028C>A p.L2010M RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117317250G>T c.6028C>A p.L2010M RefSeq GRCh38/hg38
XM_011536049.3 chr6:g.117318195G>T c.6028C>A p.L2010M RefSeq GRCh38/hg38

Filtering

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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References