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Gene ROS1
Variant G1957A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 G1957A lies within the protein kinase domain of the Ros1 protein (UniProt.org). G1957A has been associated with resistance to Ros1 tyrosine kinase inhibitors in the context of a ROS1 fusion in patients (PMID: 38416709), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 G1957A

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Transcript NM_002944.3
gDNA chr6:g.117319938C>G
cDNA c.5870G>C
Protein p.G1957A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017011173.2 chr6:g.117319896C>G c.5870G>C p.G1957A RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117319938C>G c.5870G>C p.G1957A RefSeq GRCh38/hg38
XM_006715548.5 chr6:g.117319923C>G c.5870G>C p.G1957A RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References