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Gene | ROS1 |
Variant | G1957A |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ROS1 G1957A lies within the protein kinase domain of the Ros1 protein (UniProt.org). G1957A has been associated with resistance to Ros1 tyrosine kinase inhibitors in the context of a ROS1 fusion in patients (PMID: 38416709), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024). |
Associated Drug Resistance | Y |
Category Variants Paths |
ROS1 mutant ROS1 G1957A |
Transcript | NM_002944.3 |
gDNA | chr6:g.117319938C>G |
cDNA | c.5870G>C |
Protein | p.G1957A |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_006715548.5 | chr6:g.117319923C>G | c.5870G>C | p.G1957A | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117319938C>G | c.5870G>C | p.G1957A | RefSeq | GRCh38/hg38 |
XM_017011173.2 | chr6:g.117319896C>G | c.5870G>C | p.G1957A | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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