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Gene KIT
Variant T574_P577del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions KIT T574_P577del (also referred to as P573_L576del) results in the deletion of four amino acids in the juxtamembrane domain (exon 11) of the Kit protein from amino acids 574 to 577 (PMID: 16226710). T574_P577del is associated with resistance to KIT inhibitors (PMID: 38408285) and has not been characterized, however similar Kit exon 11 deletions are activating (PMID: 9438854, PMID: 15365079), and therefore, is predicted to lead to a gain of Kit protein function.
Associated Drug Resistance Y
Category Variants Paths

KIT mutant KIT act mut KIT exon 11 del KIT T574_P577del

KIT mutant KIT exon11 KIT exon 11 del KIT T574_P577del

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Transcript NM_000222.3
gDNA chr4:g.54727488_54727499del12
cDNA c.1720_1731del12
Protein p.T574_P577del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000222.3 chr4:g.54727488_54727499del12 c.1720_1731del12 p.T574_P577del RefSeq GRCh38/hg38
NM_001385285.1 chr4:g.54727488_54727499del12 c.1720_1731del12 p.T574_P577del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References