NRAS G75_E76insDSAMRDQYMRTG
Gene Variant Detail

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Gene NRAS
Variant G75_E76insDSAMRDQYMRTG
Impact List insertion
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G75_E76insDSAMRDQYMRTG results in the insertion of 12 amino acids in the Nras protein between amino acids 75 and 76 (UniProt.org). G75_E76insDSAMRDQYMRTG results in increased immature myeloid cells in a zebrafish model (PMID: 38522505), and therefore, is predicted to lead to a loss of Nras protein function resulting in activation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G75_E76insDSAMRDQYMRTG

NRAS mutant NRAS exon3 NRAS G75_E76insDSAMRDQYMRTG

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Transcript NM_002524.5
gDNA chr1:g.114713864_114713865insACCTGTCCTCATATATTGGTCCCTCATTGCGCTGTC
cDNA c.227_228insCAGCGCAATGAGGGACCAATATATGAGGACAGGTGA
Protein p.G75_E76insDSAMRDQYMRTG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114713864_114713865insACCTGTCCTCATATATTGGTCCCTCATTGCGCTGTC c.227_228insCAGCGCAATGAGGGACCAATATATGAGGACAGGTGA p.G75_E76insDSAMRDQYMRTG RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G75_E76insDSAMRDQYMRTG myelodysplastic/myeloproliferative neoplasm sensitive Mirdametinib Preclinical Actionable In a preclinical study, Gomekli (mirdametinib) decreased the accumulation of immature myeloid cells in a zebrafish model of myelodysplastic/myeloproliferative neoplasm harboring NRAS G75_E76insDSAMRDQYMRTG (PMID: 38522505). 38522505
NRAS G75_E76insDSAMRDQYMRTG myelodysplastic/myeloproliferative neoplasm sensitive Trametinib Preclinical Actionable In a preclinical study, Mekinist (trametinib) decreased the accumulation of immature myeloid cells in a zebrafish model of myelodysplastic/myeloproliferative neoplasm harboring NRAS G75_E76insDSAMRDQYMRTG (PMID: 38522505). 38522505