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Gene NRAS
Variant G75_E76insDSAMRDQYMRTG
Impact List insertion
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G75_E76insDSAMRDQYMRTG results in the insertion of 12 amino acids in the Nras protein between amino acids 75 and 76 (UniProt.org). G75_E76insDSAMRDQYMRTG results in increased immature myeloid cells in a zebrafish model (PMID: 38522505), and therefore, is predicted to lead to a loss of Nras protein function resulting in activation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G75_E76insDSAMRDQYMRTG

NRAS mutant NRAS exon3 NRAS G75_E76insDSAMRDQYMRTG

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Transcript NM_002524.5
gDNA chr1:g.114713864_114713865insACCTGTCCTCATATATTGGTCCCTCATTGCGCTGTC
cDNA c.227_228insCAGCGCAATGAGGGACCAATATATGAGGACAGGTGA
Protein p.G75_E76insDSAMRDQYMRTG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114713864_114713865insACCTGTCCTCATATATTGGTCCCTCATTGCGCTGTC c.227_228insCAGCGCAATGAGGGACCAATATATGAGGACAGGTGA p.G75_E76insDSAMRDQYMRTG RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
NRAS G75_E76insDSAMRDQYMRTG loss of function - predicted