ERBB3 N353T
Gene Variant Detail

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Gene ERBB3
Variant N353T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ERBB3 (HER3) N353T lies within the extracellular domain of the Erbb3 (Her3) protein (UniProt.org). N353T results in increased IL3-independent growth upon co-expression with ERBB2 (HER2) V956R, an impaired activator of homodimerization, in culture (PMID: 38806620), and therefore, is predicted to lead to a gain of Erbb3 (Her3) protein function.
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 act mut ERBB3 N353T

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Transcript NM_001982.4
gDNA chr12:g.56088817A>C
cDNA c.1058A>C
Protein p.N353T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982.4 chr12:g.56088817A>C c.1058A>C p.N353T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
ERBB3 N353T gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor HER3 Inhibitor