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Gene PIK3CA
Variant D1029Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA D1029Y lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). D1029Y confers a gain of function to the Pik3ca protein, as demonstrated by increased phosphorylation of Akt and transformation of cells in culture (PMID: 19394761).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA D1029Y

PIK3CA mutant PIK3CA exon21 PIK3CA D1029Y

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Transcript NM_006218.4
gDNA chr3:g.179234242G>T
cDNA c.3085G>T
Protein p.D1029Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38
XM_011512894 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179234242G>T c.3085G>T p.D1029Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA D1029Y gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
PIK3CA D1029Y PTEN loss
PIK3CA D1029Y PTEN inact mut