FGFR2 V169_K176delinsE - Gene Variant Detail

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Gene FGFR2
Variant V169_K176delinsE
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FGFR2 V169_K176delinsE results in a deletion of eight amino acids from aa 169 to aa 176 within Ig-like C2-type domain 2 of the Fgfr2 protein, combined with the insertion of a glutamic acid (E) at the same site (UniProt.org). V169_K176delinsE has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Feb 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon5 FGFR2 exon 5 del FGFR2 V169_K176delinsE

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Transcript NM_000141.5
gDNA chr10:g.121551388_121551408del21
cDNA c.506_526del21
Protein p.V169_K176delinsE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144917.2 chr10:g.121551388_121551408del21 c.506_526del21 p.V169_K176delinsE RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121551388_121551408del21 c.506_526del21 p.V169_K176delinsE RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121551388_121551408del21 c.506_526del21 p.V169_K176delinsE RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121551388_121551408del21 c.506_526del21 p.V169_K176delinsE RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121551388_121551408del21 c.506_526del21 p.V169_K176delinsE RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121551388_121551408del21 c.506_526del21 p.V169_K176delinsE RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References