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Gene JAK2
Variant L902Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions JAK2 L902Q lies within protein kinase domain 2 of the Jak2 protein (UniProt.org). L902Q does not result in cytokine-independent growth and is associated with resistance to Jak2 inhibitors in the context of JAK2 V617F in culture (PMID: 39091915), but has not been fully biochemically characterized and therefore, its effect on Jak2 protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

JAK2 mutant JAK2 L902Q

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Transcript NM_004972.4
gDNA chr9:g.5089807T>A
cDNA c.2705T>A
Protein p.L902Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001322196.2 chr9:g.5089807T>A c.2705T>A p.L902Q RefSeq GRCh38/hg38
NM_004972.4 chr9:g.5089807T>A c.2705T>A p.L902Q RefSeq GRCh38/hg38
NM_001322195.2 chr9:g.5089807T>A c.2705T>A p.L902Q RefSeq GRCh38/hg38
NM_001322194.2 chr9:g.5089807T>A c.2705T>A p.L902Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
JAK2 L902Q unknown
JAK2 V617F JAK2 L902Q
JAK2 V617F JAK2 L902Q JAK2 R938E
JAK2 V617F JAK2 L902Q JAK2 R947Q
JAK2 V617F JAK2 L902Q JAK2 E1028K