FGFR2 I549T
Gene Variant Detail

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Gene FGFR2
Variant I549T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 I549T (corresponds to I548T in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). I549T has been identified in the scientific literature (PMID: 39226398), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 I549T

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Transcript NM_001144913.1
gDNA chr10:g.121498524A>G
cDNA c.1646T>C
Protein p.I549T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121498524A>G c.1646T>C p.I549T RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498524A>G c.1646T>C p.I549T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References