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Gene ARID1A
Variant Y1324*
Impact List nonsense
Protein Effect loss of function
Gene Variant Descriptions ARID1A Y1324* results in a premature truncation of the Arid1a protein at amino acid 1324 of 2285 (UniProt.org). Y1324* confers a loss of function to Arid1a as demonstrated by decreased binding with Baf subunits, decreased inhibition of proliferation, and failure to induce senescence in culture (PMID: 34386776).
Associated Drug Resistance
Category Variants Paths

ARID1A mutant ARID1A inact mut ARID1A Y1324*

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Transcript NM_006015.6
gDNA chr1:g.26773685C>A
cDNA c.3972C>A
Protein p.Y1324*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006015.6 chr1:g.26773685C>A c.3972C>A p.Y1324* RefSeq GRCh38/hg38
NM_139135.4 chr1:g.26773685C>A c.3972C>A p.Y1324* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References