Gene Variant Detail

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Gene TP53
Variant G199E
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 G199E lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). G199E results in increased colony formation compared to wild-type Tp53 in the presence of an MDM2 antagonist and leads to tumor growth in mouse models (PMID: 35165384), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 G199E

TP53 mutant TP53 inact mut TP53 G199E

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Transcript NM_000546.6
gDNA chr17:g.7674935C>T
cDNA c.596G>A
Protein p.G199E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674935C>T c.596G>A p.G199E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References