APC I2738T
Gene Variant Detail

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Gene APC
Variant I2738T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC I2738T lies within a region of the Apc protein necessary for interaction with DLG1 and MAPRE1 (UniProt.org). I2738T has been identified in sequencing studies (PMID: 9950360), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

APC mutant APC I2738T

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Transcript NM_000038.6
gDNA chr5:g.112843807T>C
cDNA c.8213T>C
Protein p.I2738T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.112843807T>C c.8213T>C p.I2738T RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112843807T>C c.8213T>C p.I2738T RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112843807T>C c.8213T>C p.I2738T RefSeq GRCh38/hg38
NM_001127511.3 chr5:g.112843861T>C c.8213T>C p.I2738T RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112843807T>C c.8213T>C p.I2738T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References