Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene CDK12
Variant R701*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions CDK12 R701* results in a premature truncation of the Cdk12 protein at amino acid 701 of 1490 (UniProt.org). R701* results in loss of binding to Ccnk in cell culture (PMID: 39321214), and therefore, is predicted to lead to a loss of Cdk12 protein function.
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 R701*

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_016507.4
gDNA chr17:g.39490726A>T
cDNA c.2101A>T
Protein p.R701*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436276.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39490726A>T c.2101A>T p.R701* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDK12 R701* prostate cancer sensitive Rucaparib Preclinical - Cell culture Actionable In a preclinical study, Rubraca (rucaparib) treatment inhibited viability of a CDK12 knockout prostate cancer cell line expressing CDK12 R701* in culture (PMID: 39321214). 39321214