PIK3CA E453V
Gene Variant Detail

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Gene PIK3CA
Variant E453V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA E453V lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). E453V has been identified in sequencing studies (PMID: 27135926), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2026).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA E453V

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Transcript NM_006218.4
gDNA chr3:g.179210292A>T
cDNA c.1358A>T
Protein p.E453V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179210292A>T c.1358A>T p.E453V RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210292A>T c.1358A>T p.E453V RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07522697 Phase II Inavolisib Inavolisib for PIK3CA Mutated Advanced Endometrial Cancer: MITO END-4 (MITO END-4) Not yet recruiting ITA 0