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Gene PTEN
Variant L112I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PTEN L112I lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). L112I has not been characterized and therefore, its effect on Pten protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN L112I

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Transcript NM_000314.8
gDNA chr10:g.87933093C>A
cDNA c.334C>A
Protein p.L112I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87933093C>A c.334C>A p.L112I RefSeq GRCh38/hg38
NM_001304717.2 chr10:g.87864284_87864286delCTGinsATC c.334_336delCTGinsATC p.L112I RefSeq GRCh38/hg38
NM_001304717.5 chr10:g.87864284_87864286delCTGinsATC c.334_336delCTGinsATC p.L112I RefSeq GRCh38/hg38
NM_001304717 chr10:g.87864284_87864286delCTGinsATC c.334_336delCTGinsATC p.L112I RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87933093C>A c.334C>A p.L112I RefSeq GRCh38/hg38
NM_000314 chr10:g.87933093C>A c.334C>A p.L112I RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References