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Gene PTEN
Variant R15K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN R15K lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). R15K results in nuclear localization similar to wild-type Pten, but results in a loss of phosphatase activity in culture (PMID: 25875300), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN R15K

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Transcript NM_000314.8
gDNA chr10:g.87864513G>A
cDNA c.44G>A
Protein p.R15K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87864513G>A c.44G>A p.R15K RefSeq GRCh38/hg38
NM_000314 chr10:g.87864513G>A c.44G>A p.R15K RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87864513G>A c.44G>A p.R15K RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References