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Gene PTEN
Variant S10I
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN S10I lies within the lipid binding domain of the Pten protein (PMID: 25263454). S10I results in reduced phosphatase activity in a yeast assay (PMID: 29706350), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN S10I

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Transcript NM_000314.8
gDNA chr10:g.87864498G>T
cDNA c.29G>T
Protein p.S10I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87864498G>T c.29G>T p.S10I RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87864498G>T c.29G>T p.S10I RefSeq GRCh38/hg38
NM_001304718.2 chr10:g.87952245G>T c.29G>T p.S10I RefSeq GRCh38/hg38
NM_001304718.1 chr10:g.87952245G>T c.29G>T p.S10I RefSeq GRCh38/hg38
NM_001304718 chr10:g.87952245G>T c.29G>T p.S10I RefSeq GRCh38/hg38
NM_000314 chr10:g.87864498G>T c.29G>T p.S10I RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References