FGFR2 L262_A266delinsD
Gene Variant Detail

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Gene FGFR2
Variant L262_A266delinsD
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FGFR2 L262_A266delinsD results in a deletion of five amino acids from aa 262 to aa 266 within Ig-like C2-type domain 3 of the Fgfr2 protein, combined with the insertion of an aspartic acid (D) at the same site (UniProt.org). L262_A266delinsD has been identified in the scientific literature (PMID: 39706336), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 exon 7 del FGFR2 L262_A266delinsD

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Transcript NM_000141.5
gDNA chr10:g.121520120_121520134delinsGTC
cDNA c.784_798delinsGAC
Protein p.L262_A266delinsD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.2 chr10:g.121520120_121520134delinsGTC c.784_798delinsGAC p.L262_A266delinsD RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520120_121520134delinsGTC c.784_798delinsGAC p.L262_A266delinsD RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520120_121520134delinsGTC c.784_798delinsGAC p.L262_A266delinsD RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520120_121520134delinsGTC c.784_798delinsGAC p.L262_A266delinsD RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520120_121520134delinsGTC c.784_798delinsGAC p.L262_A266delinsD RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References