BARD1 P187A
Gene Variant Detail

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Gene BARD1
Variant P187A
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions BARD1 P187A does not lie within any known functional domains of the Bard1 protein (UniProt.org). P187A results in altered subcellular localization, decreased Brca1, Palb2, and Rad51c interaction, impaired homology-directed DNA repair activity, decreased DNA repair post-irradiation, decreased H2A ubiquitination, and increased sensitivity to olaparib and cisplatin treatment in cultured cells (PMID: 39387837).
Associated Drug Resistance
Category Variants Paths

BARD1 mutant BARD1 inact mut BARD1 P187A

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Transcript NM_000465.4
gDNA chr2:g.214781315G>C
cDNA c.559C>G
Protein p.P187A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000465.4 chr2:g.214781315G>C c.559C>G p.P187A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries