ARID1A Q909*
Gene Variant Detail

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Gene ARID1A
Variant Q909*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ARID1A Q909* results in a premature truncation of the Arid1a protein at amino acid 909 of 2285 (UniProt.org). Q909* has not been characterized, however, due to the effects of other truncation mutations downstream of Q909 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
Associated Drug Resistance
Category Variants Paths

ARID1A mutant ARID1A inact mut ARID1A Q909*

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Transcript NM_006015.6
gDNA chr1:g.26763278C>T
cDNA c.2725C>T
Protein p.Q909*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006015.6 chr1:g.26763278C>T c.2725C>T p.Q909* RefSeq GRCh38/hg38
NM_139135.4 chr1:g.26763278C>T c.2725C>T p.Q909* RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A Q909* skin melanoma predicted - sensitive Niraparib Case Reports/Case Series Actionable In a Phase II clinical trial, Zejula (niraparib) therapy demonstrated activity in melanoma patients harboring mutations in HRR pathway genes, resulting in a partial response (PR) rate of 14% (2/14) and disease control rate (DCR) of 64% (9/14), with stable disease in 7 patients and a median progression-free survival of 16 weeks; response rate was 20% (2/10, 2 PR) and DCR was 70% (7/10) in patients with non-uveal melanoma, including a PR in a cutaneous melanoma patient harboring ARID1A Q909* (PMID: 40373259). 40373259