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Gene NRAS
Variant G12P
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12P is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12P has not been characterized, but can be predicted to lead to a loss of Nras protein function based on the effect of HRAS G12P, which demonstrates intrinsic hydrolysis rate similar to wild-type protein but has decreased affinity for GTPase-activating proteins, and is not transforming in cell culture (PMID: 6092966, PMID: 8357792).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12P

NRAS mutant NRAS exon2 NRAS G12X NRAS G12P

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Transcript NM_002524.5
gDNA chr1:g.114716126_114716127delGGinsCC
cDNA c.34_35delGGinsCC
Protein p.G12P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114716126_114716127delCCinsGG c.34_35delGGinsCC p.G12P RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114716126_114716127delGGinsCC c.34_35delGGinsCC p.G12P RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716126_114716127delGGinsCC c.34_35delGGinsCC p.G12P RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References