NRAS S65G
Gene Variant Detail

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Gene NRAS
Variant S65G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS S65G lies within the switch II domain of the Nras protein (PMID: 17384584). S65G has been identified in sequencing studies (PMID: 35330454), but has not been biochemically characterized and therefore, its effect on Nras protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon3 NRAS S65G

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Transcript NM_002524.5
gDNA chr1:g.114713897T>C
cDNA c.193A>G
Protein p.S65G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713897T>C c.193A>G p.S65G RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713897T>C c.193A>G p.S65G RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713897T>C c.193A>G p.S65G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References