FLT3 I836delinsLD
Gene Variant Detail

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Gene FLT3
Variant I836delinsLD
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FLT3 I836delinsLD results in the deletion of isoleucine (I) at amino acid 836 in the protein kinase domain of the Flt3 protein, combined with the insertion of a leucine (L) and an aspartic acid (D) at the same site (UniProt.org). I836delinsLD has been identified in the scientific literature (PMID: 40196870), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 I836delinsLD

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Transcript NM_004119.3
gDNA chr13:g.28018500_28018502delinsGTCAAG
cDNA c.2506_2508delinsCTTGAC
Protein p.I836delinsLD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018500_28018502delinsGTCAAG c.2506_2508delinsCTTGAC p.I836delinsLD RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 I836delinsLD hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) treatment decreased viability in a cell line expressing FLT3 I836delinsLD in culture (PMID: 40196870). 40196870
FLT3 I836delinsLD hematologic cancer sensitive Quizartinib Preclinical - Cell culture Actionable In a preclinical study, Vanflyta (quizartinib) treatment decreased viability in a cell line expressing FLT3 I836delinsLD in culture (PMID: 40196870). 40196870
FLT3 I836delinsLD hematologic cancer sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) treatment decreased viability in a cell line expressing FLT3 I836delinsLD in culture (PMID: 40196870). 40196870