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| Gene | FLT3 |
| Variant | I836delinsLD |
| Impact List | indel |
| Protein Effect | unknown |
| Gene Variant Descriptions | FLT3 I836delinsLD results in the deletion of isoleucine (I) at amino acid 836 in the protein kinase domain of the Flt3 protein, combined with the insertion of a leucine (L) and an aspartic acid (D) at the same site (UniProt.org). I836delinsLD has been identified in the scientific literature (PMID: 40196870), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Sep 2025). |
| Associated Drug Resistance | |
| Category Variants Paths |
FLT3 mutant FLT3 exon20 FLT3 I836delinsLD |
| Transcript | NM_004119.3 |
| gDNA | chr13:g.28018500_28018502delinsGTCAAG |
| cDNA | c.2506_2508delinsCTTGAC |
| Protein | p.I836delinsLD |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_004119.3 | chr13:g.28018500_28018502delinsGTCAAG | c.2506_2508delinsCTTGAC | p.I836delinsLD | RefSeq | GRCh38/hg38 |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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