FLT3 D593del
Gene Variant Detail

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Gene FLT3
Variant D593del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions FLT3 D593del results in the deletion of an amino acid in the juxtamembrane domain of the Flt3 protein at amino acid 593 (PMID: 14759363). D593del has been identified in the scientific literature (PMID: 40196870), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 D593del

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Transcript NM_004119.3
gDNA chr13:g.28034141_28034143delTCA
cDNA c.1777_1779delGAT
Protein p.D593del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28034141_28034143delTCA c.1777_1779delGAT p.D593del RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 D593del hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) treatment decreased viability in a cell line expressing FLT3 D593del in culture (PMID: 40196870). 40196870
FLT3 D593del hematologic cancer sensitive Quizartinib Preclinical - Cell culture Actionable In a preclinical study, Vanflyta (quizartinib) treatment decreased viability in a cell line expressing FLT3 D593del in culture (PMID: 40196870). 40196870
FLT3 D593del hematologic cancer sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) treatment decreased viability in a cell line expressing FLT3 D593del in culture (PMID: 40196870). 40196870