FGFR1 A354V
Gene Variant Detail

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Gene FGFR1
Variant A354V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 A354V lies within Ig-like C2-type domain 3 of the Fgfr1 protein (UniProt.org). A354V has been identified in the scientific literature (PMID: 37889382), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 A354V

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Transcript NM_023110.3
gDNA chr8:g.38421817G>A
cDNA c.1061C>T
Protein p.A354V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023110.3 chr8:g.38421817G>A c.1061C>T p.A354V RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38421817G>A c.1061C>T p.A354V RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 A354V esophageal carcinoma predicted - sensitive Pemigatinib Case Reports/Case Series Actionable In a Phase I trial, Pemazyre (pemigatinib) treatment resulted in an objective response rate of 16.7% (2/12, both partial responses) and a disease control rate of 41.7% (5/12) in patients with advanced solid tumors harboring FGFR1/2/3 alterations including amplification, mutation, or fusion, including a partial response in a patient with esophageal carcinoma harboring FGFR1 A354V (PMID: 37889382; NCT04258527). 37889382