NRAS G12H
Gene Variant Detail

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Gene NRAS
Variant G12H
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12H is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12H results in Erk and Stat5 phosphorylation to similar levels of wild-type Nras, and transforming activity comparable to NRAS G12D in culture (PMID: 35211470), and therefore, is predicted to lead to a loss of Nras protein function and activation of downstream signaling based on the effects of other NRAS G12 mutations.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12H

NRAS mutant NRAS exon2 NRAS G12X NRAS G12H

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Transcript NM_002524.5
gDNA chr1:g.114716126_114716127delGGinsCA
cDNA c.34_35delGGinsCA
Protein p.G12H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716126_114716127delGGinsCA c.34_35delGGinsCA p.G12H RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
NRAS G12H loss of function - predicted