FGFR1 P283L
Gene Variant Detail

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Gene FGFR1
Variant P283L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 P283L lies within Ig-like C2-type domain 3 of the Fgfr1 protein (UniProt.org). P283L does not significantly alter serum dependency for growth in cell culture (PMID: 40526877), but has not been fully biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 P283L

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Transcript NM_023110.3
gDNA chr8:g.38424597G>A
cDNA c.848C>T
Protein p.P283L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001174063.2 chr8:g.38424597G>A c.848C>T p.P283L RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38424597G>A c.848C>T p.P283L RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References