FGFR1 D218N
Gene Variant Detail

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Gene FGFR1
Variant D218N
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR1 D218N lies within Ig-like C2-type domain 2 of the Fgfr1 protein (UniProt.org). D218N results in increased serum dependency for growth in culture (PMID: 40526877), and therefore, is predicted to lead to a loss of Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 inact mut FGFR1 D218N

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Transcript NM_023110.3
gDNA chr8:g.38426215C>T
cDNA c.652G>A
Protein p.D218N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023110.3 chr8:g.38426215C>T c.652G>A p.D218N RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38426215C>T c.652G>A p.D218N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References