FGFR2 T320M
Gene Variant Detail

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Gene FGFR2
Variant T320M
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 T320M lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). T320M results in colony formation similar to wild-type Fgfr2 but decreased serum dependency for growth in culture (PMID: 40526877), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 T320M

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Transcript NM_000141.5
gDNA chr10:g.121517444G>A
cDNA c.959C>T
Protein p.T320M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.2 chr10:g.121517444G>A c.959C>T p.T320M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121517444G>A c.959C>T p.T320M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 T320M gain of function - predicted