FGFR2 H254Y
Gene Variant Detail

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Gene FGFR2
Variant H254Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 H254Y lies within the extracellular domain of the Fgfr2 protein (UniProt.org). H254Y leads to a gain of Fgfr2 protein function as indicated by decreased serum dependency for growth and anchorage-independent colony formation in culture (PMID: 40526877).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 H254Y

FGFR2 mutant FGFR2 exon7 FGFR2 H254Y

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Transcript NM_000141.5
gDNA chr10:g.121520158G>A
cDNA c.760C>T
Protein p.H254Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121520158G>A c.760C>T p.H254Y RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520158G>A c.760C>T p.H254Y RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520158G>A c.760C>T p.H254Y RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520158G>A c.760C>T p.H254Y RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520158G>A c.760C>T p.H254Y RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 H254Y Advanced Solid Tumor sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, Balversa (erdafitinib) inhibited viability of cells expressing FGFR2 H254Y in culture (PMID: 40526877). 40526877
FGFR2 H254Y Advanced Solid Tumor sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, Fexagratinib (AZD4547) inhibited viability of cells expressing FGFR2 H254Y in culture (PMID: 40526877). 40526877
FGFR2 H254Y Advanced Solid Tumor sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, Lytgobi (futibatinib) inhibited viability of cells expressing FGFR2 H254Y in culture (PMID: 40526877). 40526877
FGFR2 H254Y Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, Pemazyre (pemigatinib) inhibited viability of cells expressing FGFR2 H254Y in culture (PMID: 40526877). 40526877